01.13.10

Prions Can Evolve

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this article discussing prions and the fact that they do mutate and evolve like viruses. Prions are degenerate proteins responsible for diseases such as “mad cow disease”, technically termed bovine spongiform encephalopathy (BSE), and Creutzfeldt Jakob disease (CJD).

In the classic sense, prions, which are 

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misfolded versions of the brain protein PrP, cannot mutate because they do not contain DNA or RNA. They can, however, give rise to variants with different properties, possibly due to differences in the folding, or shape, of the proteins. In the study, published December 31 in Science Express

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, researchers estimated the rate at which prion mutants can appear in cultured human nerve cells. In addition, the study suggests that once variants appear, they persist at low levels, giving rise to a heterogeneous prion population.

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